Neuronal Coordination of Nutrient-Associated Genes and Brain Development

Previous Science Note

This article focusing on how mammalian neurons coordinate the expression of a nutrient-associated gene with the regulation of neuronal activity to ensure proper brain development. We believe that these findings can offer valuable insights into human brain metabolism.

Large neutral amino acid levels tune perinatal neuronal excitability and survival
Lisa Knaus, et. al., Cell, 186, 1-18 (2023)

   Point of Interest
   - Metabolic reprogramming of the cerebral cortex throughout development

   - Essential role of large neutral amino acids in perinatal neuronal metabolic state

   - Link between Slc7a5 deletion in neurons, branched-chain amino acids, and lipid metabolism

   - Impact of reduced large neutral amino acid levels on neuronal excitability and survival
Related Techniques
Glycolysis/Oxidative phosphorylation assay
Glycolysis/OXPHOS Assay Kit
Oxygen consumption rate assay
Extracellular OCR Plate Assay Kit
Glycolysis-related metabolites assay
Glucose and Lactate ​Assay Kit
TCA cycle-related metabolites assay
Glutamine, Glutamate, and α-KG Assay Kit 
NAD(H) and NADP(H) redox couples assay
NAD/NADH and NADP/NADPH Assay Kit 
ATP Assay
ATP Assay Kit and ADP/ATP Assay Kit
Nutrient uptake Assay
Glucose (Blue / Green / Red), Amino Acid, Cystine, and Fatty Acid Uptake Assay Kit 
Lipid droplets detection
Lipi-Blue / Green / Red / Deep Red
 
 
Related Applications

＜The metabolic shift to glycolysis under the treatment of fatty acid transporter inhibitors＞

Products in Use
for Fatty Acid Uptake Assay
  ① Fatty Acid Uptake Assay Kit

for Cell Proliferation/Cytotoxicity Assay
  ② Cell Counting Kit-8

for Glycolysis Assay
  ③ Glucose Assay Kit-WST
  ④ Lactate Assay Kit-WST

Related Products
for Glycolysis and OXPHOS Assay
  - Glycolysis/OXPHOS Assay Kit

for OXPHOS Assay
  - Extracellular OCR Plate Assay Kit

 

Product Classification

Product Classification

Search word