Science Note
[Sep. 26, 2023] Previous Science Note
Senescence Related to Reprogramming and Regeneration
Scientists have discovered that, in the absence of resident stem cells, senescent cells can instruct neighboring somatic cells to reprogram. This reprogramming enables them to become stem cells, driving whole-body regeneration in the cnidarian Hydractinia symbiolongicarpus. |
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Senescence-induced cellular reprogramming drives cnidarian whole-body regeneration |
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Point of Interest |
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Related Techniques | |||
First choice for cellular senescence assay | Cellular Senescence Detection Kit – SPiDER-ßGal NOW Promotion | ||
Cellular senescence assay with a plate reader | Cellular Senescence Plate Assay Kit – SPiDER-ßGal | ||
Mitophagy detection | Mitophagy Detection Kit and Mtphagy Dye | ||
Cell cycle assay | Cell Cycle Assay Solution Blue / Deep Red | ||
Dead cell staining for flow cytometry | Dead Cell Makeup Blue / Deep Red - Higher Retention than PI NEW | ||
Lysosomal pH detection | Lysosomal Acidic pH Detection Kit-Green/Red, Green/Deep Red NEW | ||
Mitochondrial function/glycolysis detection | Glycolysis/JC-1 MitoMP Assay Kit NEW | ||
Oxygen consumption rate assay | Extracellular OCR Plate Assay Kit | ||
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Related Applications | |||
Regulating Cell Cycle Arrest: p16, p21, p53, and pRB | |||
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Irreversible cell cycle arrest is one of the phenomena that characterize cellular senescence. p16, p21, p53, and pRB (phosphorylated retinoblastoma protein) are known as representative protein markers. The activation/upregulation of these proteins are used as indicators of cellular senescence. These marker proteins are known to be tumor suppressors and regulate the cell cycle mainly through two pathways (p16Ink4a-RB and p53-p21CIP1).
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