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Scientists have unveiled that senescence is irreversible and that commitment to and maintenance of senescence is mediated by irreversible MYC degradation. Thus, irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation, but bypassing this degradation may allow tumor cells to escape during cancer initiation. |
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Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation |
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Point of Interest |
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| Related Techniques | |||
| First choice for cellular senescence assay | Cellular Senescence Detection Kit – SPiDER-ßGal | ||
| Cellular senescence assay with a plate reader | Cellular Senescence Plate Assay Kit – SPiDER-ßGal | ||
| Cell cycle assay | Cell Cycle Assay Solution Blue / Deep Red | ||
| Lysosomal pH detection | Lysosomal Acidic pH Detection Kit-Green/Red, Green/Deep Red | ||
| Mitochondrial function/glycolysis detection | Glycolysis/JC-1 MitoMP Assay Kit | ||
| Oxygen consumption rate assay | Extracellular OCR Plate Assay Kit | ||
| Related Applications | |||
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Metabolic shift to glycolysis in senescenct cellsNAD(+) levels decline during the aging process, causing defects in nuclear and mitochondrial functions and resulting in many age-associated pathologies*. Here, we try to redemonstrate this phenomenon in the doxorubicin (DOX)-induced cellular senescence model with a comprehensive analysis of our products. *S. Imai, et al., Trends Cell Biol, 2014, 24, 464-471
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