09 Cross-Linking Reagents

Isothiocyanobenzyl-EDTA

Isothiocyanobenzyl-EDTA

Chelate Labeling Reagent

  • Product code
    M030  Isothiocyanobenzyl-EDTA
  • CAS No.
    105394-74-9
  • Chemical name
    1-(4-IsothiOcyanatobenzyl)ethylenediamine-N,N,N',N'-tetraacetic acid
  • MW
    C18H21N3O8S=439.44
Unit size Price Item Code
10 mg $522.00 M030-10
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Product Description of Amine-Reactive Biotins

Isothiocyanobenzyl-EDTA adds EDTA moieties to proteins through their amine groups. The EDTA-tagged protein can then be labeled with heavy metal ions and radioactive metals, such as 111In and 99Tc, and used for immunoimaging.

Chemical Structure

Technical info

References

Open References

1) C. F. Meares and T. G. Wensel, "Metal Chelates as Probes of Biological Systems", Acc. Chem. Res., 198417, 202.
2) S. V. Deshpande, R. Subramanian, M. J. McCall, S. J. Denardo, G. L. Denardo and C. F. Meares, "Metabolism of Indium Chelates Attached to Monoclonal Antibody: Minimal Transchelation of Indium form Benzyl-EDTA Chelate in vivo", J. Nucl. Med.199031, 218.
3) S. Mirzadeh, M. W. Brechbiel, R. W. Atcher and O. A. Gansow, "Radiometal Labeling of Immunoproteins: Covalent Linkage of 2-(4-Isothiocyanatobenzyl)diethylenetriaminepentaacetic acid Ligands to Immunoglobulin", Bioconjugate Chem.19901, 59.

Handling and storage condition

Specification
Appearance: White to slightly yellowish brown powder
Purity (HPLC): ≧ 90.0 %
IR spectrum: Authentic
Handling and storage condition
-20°C, Protect from moisture
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Product Classification

Product Classification

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