-SulfoBiotics- Sodium Polysulfide Set
Product codeSB13 -SulfoBiotics- Sodium Polysulfide Set
|Unit size||Price||Item Code|
|Sodium disulfide (Na2S2)||100 mg x1|
|Sodium trisulfide (Na2S3)||100 mg x1|
|Sodium tetrasulfide (Na2S4)||100 mg x1|
It becomes obvious that there are a lot of molecules containing sulfane sulfurs such as persulfides and polysulfides in living organism. These molecular species are involved in production, storage, and release of hydrogen sulfide, which is recognized as an important physiological mediator. Furthermore, recent studies reveal that persulfides and polysulfides may control intracellular signal transduction through s-sulfhydration of proteins, and function in vivo as anti-oxidants which have much higher reducing activity than glutathione in reduced form or cysteine.
Sodium polysulfides (Na2Sn) are sulfane sulfur donors which have simple structures, and exist as hydrogen polysulfides in an aqueous solution depending on pH. These reagents are necessary to for research and analysis of sulfane sulfurs in vivo.
|Developer||Dojindo Molecular Technologies, Inc.|
1) Y. Kimura, Y. Mikami, K. Osumi, M. Tsugane, J. Oka, and H. Kimura, "Polysulfides are possible H2S-derived signaling molecules in rat brain", FASEB J., 2013, 27, 2451.
2) S. Koike, Y. Ogasawara, N. Shibuya, H. Kimura, and K. Ishii, "Polysulfide exerts a protective effect against cytotoxicity caused by t-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells", FEBS Lett., 2013, 587, 3548
3) E. R. DeLeon, Y. Gao, E. Huang, M. Arif, N. Arora, A. Divietro, S. Patel, and K. R. Olson , "A case of mistaken identity: are reactive oxygen species actually reactive sulfide species?", American Journal of Physiology: Regulatory, Integrative and Comparative Physiology ., 2015, 310, (7), 549.
4) D. Delgermuruna, S. Yamaguchia, O. Ichiib, Y. Konb, S. Itoa, and K. Otsuguroa, "Hydrogen sulfide activates TRPA1 and releases 5-HT from epithelioid cells of the chicken thoracic aorta", Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology., 2016, 187, 43 .
5) S. Koikea, T. Kayamaa, S. Yamamotoa, D. Kominea, R. Tanakaa, S. Nishimotoa, T. Suzukia, A. Kishidab, and Y. Ogasawaraa, "Polysulfides protect SH-SY5Y cells from methylglyoxal-induced toxicity by suppressing protein carbonylation: A possible physiological scavenger for carbonyl stress in the brain", NeuroToxicology., 2016, 55, 13 .
Handling and storage condition
|Sodium disulfide (Na2S2)：||試験適合|
|Sodium trisulfide (Na2S3)：||試験適合|
|Sodium tetrasulfide (Na2S4)：||試験適合|
|0-5°C, Protect from light, Protect from moisture|
Danger / harmful