| [Feb. 21, 2023] | Previous Science Note |
Nucleophagy and agingNucleophagy delays aging and preserves germline immortality - The nematode Caenorhabditis elegans nuclear envelope anchor protein ANC-1 and its m ammlian ortholog nesprin-2 are cleared out by autophagy and restrict the nucleolar size, a biomarker of aging. - Nucleolar degradation at the most proximal oocyte by ANC-1 and key autophagic components relates to a germline immortality. - Perturbation of this clearance pathway causes tumor-like structures in C. elegans, and genetic ablation of nesprin-2 causes ovarian carcinomas in mice. |
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