IN VITRO: CAR-CELLS DEVELOPMENT

Since LDH release assay is a most time efficien

Since LDH release assay is a most time efficient and convenient method to evaluate large quantity of CAR T-cell samples/target cell effects (different E:T ratios and/or cells types ^[1]), this assay is suitable for primary screenings.

References:
[1] Song, Y. et al (2017). Effective and persistent antitumor activity of HER2-directed CAR-T cells against gastric cancer cells in vitro and xenotransplanted tumors in vivo. Protein & Cell. doi:10.1007/s13238-017-0384-8