Chemical Name: N-Butyl-N2-acetyl-S-pivaloylsulfanyl-DL-penicillamine amide
Appearance: Colorless to white solid
Purity: ≥95.0% (HPLC)
MW: 362.55, C16H30N2O3S2
Storage Condition: 0-5℁E/font>
Thiol-activated hydrogen sulfide donor 8l and 8о prepared from penicillamine release H
2S upon reaction with reducing agents containing sulfhydryl groups such as cysteine and reduced glutathione in a similar manner to 5a. The H2S releasing rates depend on concentrations of thiols, and donor 8о gives a slower H2S releasing rate than donor 8l. These donors are useful to investigate the effects of H2S releasing rates on cellular functions. *H2S donor 8l and 8o were developed by Dr. Ming Xian of Washington State University.
Fig. 1 H2S Releasing Mechanism of Donor 8l and 8o
Fig. 2 H2S Releasing Curve of Donor 8l and 8o in PBS (100 μM) by addition of GSH (5 mM)
Y. Zhao, S. Bhushan, C. Yang, H. Otsuka, J. D. Stein, A. Pacheco, B. Peng, N. O. Devarie-Baez, H. C. Aguilar , D. J.Lefer, and M. Xian, Chem. Biol., 2013, 8, 1283.