Chemical Name: N-(Benzoylthio)benzamide
Appearance: White to slightly yellowish white powder
Purity: ≥98.0% (HPLC)
MW: 257.31, C14H11NO2S
Storage Condition: 0-5℁E/font>
Hydrogen sulfide donor 5a releases H2S upon reaction with reducing agents containing sulfhydryl groups such as cysteine and reduced glutathione. The donor is stable in aqueous solutions, whereas it decomposes and releases H2S in biological samples containing thiols such as blood, tissues or cells. This reaction mimics releasing mechanism of H2S in vivo. *H2S donor 5a was developed by Dr. Ming Xian of Washington State University.
Fig. 1 H2S Releasing Mechanism of Donor 5a
Fig. 2 H2S Releasing Curve of Donor 5a in PBS (100 μM) by addition of GSH (5 mM)
Y. Zhao, H. Wang, and M. Xian, J. Am. Chem. Soc., 2011, 133, 15.