Chemical Name: 16-Mercaptohexadecanol hexathyleneglycol ether
Appearance: White or slightly yellow solid
Purity: ≥95.0% (HPLC)
Solubility:10 mmol/L (Ethyl alcohol, Methyl alcohol, Chloroform)
MW: 538.82, C28H58O7S
Storage Condition: -20oC, protect from metal
Shipping Condition: with blue ice
Polyethyleneglycols (PEGs) are widely used
for material modifications to improve hydrophilicity of the surface.
PEG-coated materials are usually more stable under physiological
conditions. Since Hydroxy-EGn-undecanethiol has 3 or 6 ethylene glycol
units, 11 carbon atoms, and an SH group at the end, it can be used to
prepare a highly oriented and hydrophilic SAM on a gold surface that is
suitable for biomateriallabelings on the surface. This is due to the
improvement of hydrophilicity. The hydrophilic surface can prevent
proteins or other biomaterials from non-specific binding. Therefore, the
SAM prepared by this reagent will provide a better surface to develop
biomaterial sensors or DNA/protein microarrays.
Hydroxy-EGn-undecanethiols (n=3, 6) are used to dilute Carboxyl -SAM or
Amino-SAM according to the density of the molecules be introduced onto
the surface. There are several papers available on labeling proteins
such as ovalbumin and cytochrome C.
References for Aminoalkanetihiol
4. C. Pale-Grosdemange, E. S. Simon, K. L. Prime, and G. M. Whitesides, Anal. Chem., 1999, 71, 777.
5. A. Subramanian, J. Irudayaraj, and T. Ryan, Biosensors and Bioelectronics, 2006, 21, 998.
6. X. Qian, S. J. Metallo, I. S. Choi, H. Wu, M. N. Liang and G. M. Whitesides, Anal. Chem., 2002, 74, 1805.
7. M. Kyo, K.Usui-Aoki, H. Koga, Anal. Chem, 2005, 77, 7115.