Chemical Name: 4,4 EDithiodibutyric acid
Appearance: White Crystalline powder
Purity: ≥97.0% (HPLC)
MW: 238.33, C8H14O4S2Storage Condition: ambient temperature, protect from metal
Shipping Condition: ambient temperature
Product Description of Carboxyallanedisulfides
Product Description of Carboxyallanedisulfides Carboxyalkyldisulfides are oxidized carboxyalkanethiols. They
form SAMs similar to the carboxyalkanethiols, but are more stable than
thiols. Kanayama and others formed SAMs of 4,4 Edithiodibutyric acid on
gold colloids or gold electrodes and introduced phenylboronic acid
moieties to its terminus. They succeeded in recognizing various sugars
by surface-enhanced Raman spectroscopy (SERS) and cyclic voltammetry
(CV) using these SAMs. Takagi and coworkers fixed dinitrophenyl (DNP)
groups on carboxyalkyl-disulfide SAMs. They detected an anti-DNP
antibody by electrical impedance measurement. This technique could be
applied to impedimetric sensing of proteins. Delamarche and his
coworkers fabricated 10-carboxydecyl disulfide SAMs on a gold substrate
and introduced a photoactivatable benzophenone moiety to the termini.
After attaching a protein (IgG), it was tested by a variety of
characterization techniques (including ellipsometry, Xray photoelectron
spectroscopy and AFM).
1. N. Kanayama and H. Kitano, Interfacial
Recognition of Sugar by Boronic acid-Carrying self-Assembled Monolayers,
Langmuir, 2000, 16, 577.
R. D. Vaughan, C. K. O’Sullivan and G. G. Guilbault, Sulfer based
Self-assembled Monolayers(SAM’s) on Piezoelectric Crystals for
Immunosensor development, Fresenius J. Anal. Chem., 1999, 364, 54.
H. Taira, K. Nakano, M. Maeda and M. Takagi, Electrode Modification by
Long-Chain,Dialkyl Disulfide Reagent Having Terminal Dinitrophemyl Group
and Its Application to Impedimetric Immunosensors. Anal. Sci., 1993, 9, 199.
E. Delamarche, G. Sundarababu, H. Biebuyck, B. Michel, Ch. Gerber, H.
Sigrist, H. Wolf, H. Ringsdorf, N. Xanthopoulos and H. J. Mathieu,
Immobilization of Antibodies on a Photoactive Self-Assembled Monolater
on Gold, Langmuir, 1996, 12, 1997.