Chemical Name: 5-Carboxy-1-pentanethiol
Appearance: Colorless or slightly yellow liquid
Purity: ≥97.0% (HPLC)
MW: 148.22, C6H12O2S
Storage Condition: 0-5ºC, protect from metal
Shipping Condition: ambient temperature
are utilized for the modification of a gold surface to introduce
carboxylic groups on it. The carboxylic group is often converted to
activated N-hydroxysuccinimide ester, which reacts with an amine group
of biomaterials. Dojindo’s newly developed 15-Carboxy-1-pentadecanethiol
has a 15-carbon chain, which is the longest alkanethiol available in
the market among carboxyalkanethiols. Five different carboxyalkanethiols
including Carboxy-EG6-undecanethiol are available for gold surface
modification. Malone and others fabricated a highly sensitive SPR sensor
using 15-Carboxy-1-pentadecanethiol. Glenn and coworkers used
carboxyalkanethiol and poly-L-lysine to create an immobilized cytochrome
b5 multilayer electrode. Mizutani and others fabricated immobilized
glucose oxidase multilayer electrodes in a similar manner. Both groups
reported electron transfer from biomaterials to a gold surface. These
kinds of multilayer film electrodes are well suited for studies of
diffusion electron transfer. Frisbie and others developed a new method,
chemical force microscopy, for obtaining the adhesive interactions and
the friction image of patterned sample surfaces. They used atomic force
microscopy (AFM) to measure the interactions and spatial mapping of
chemically distinct functional groups. Frisbie and others formed
carboxyalkanethiol monolayers on the gold surfaces of AFM cantilever
tips. They used AFM to measure the adhesive and friction forces between
molecularly modified probe tips and organic monolayers terminating in a
lithographically defined pattern of distinct functional groups.
1. J. D. H. Glenn and E. F. Bowden, Diffusionless Electrochemistry of Cytochrome b5 Adsorbed on a Multilayer Film Electrode, Chem. Lett., 1996, 399.
2. F. Mizutani, Y. Sato, S. Yabuki and Y. Hirata, Enzyme Ultra-thin Layer Electrode Prepared by the Co-adsorption of Poly-L-lysine and Glucose Oxidase onto a Mercaptopropionic Acid-Modified Gold Surface, Chem. Lett., 1996, 251.
3. C. D. Frisbie, F. Rozsnyai, A. Noy, M. S. Wrighton and C. M. Lieber, Functional Group Imaging by Chemical Force Microscopy, Science, 1994, 265, 2071.