Chemical Name: 1-(4-Isothiocyanatobenzyl)ethylenediamine-N,N,N EN Etetraacetic acid
Appearance: White to slightly yellowish-brown powder
Purity: ≥90.0% (HPLC)
MW: 439.44, C18H21N3O8SStorage Condition: -20oC
Shipping Condition: ambient temperature
Product Description of Amine-Reactive Biotins
Isothiocyanobenzyl-EDTA adds EDTA moieties to proteins through their amine groups. The EDTA-tagged protein can then be labeled with heavy metal ions and radioactive metals, such as 111In and 99Tc, and used for immunoimaging.
1. C. F. Meares and T. G. Wensel, Metal Chelates as Probes of Biological Systems, Acc. Chem. Res.,1984, 17, 202.
2. S. V. Deshpande, R. Subramanian, M. J. McCall, S. J. Denardo, G. L. Denardo and C. F. Meares, Metabolism of Indium Chelates Attached to Monoclonal Antibody: Minimal Transchelation of Indium form Benzyl-EDTA Chelate in vivo, J. Nucl. Med., 1990, 31, 218.
3. S. Mirzadeh, M. W. Brechbiel and R. W. Atcher, Otto A. Gansow Radiometal Labeling of Immunoproteins: Covalent Linkage of 2-(4-Isothiocyanatobenzyl) diethylenetriaminepentaacetic acid Ligands to Immunoglobulin, Bioconjugate Chem., 1990, 1, 59.