20 Functional Organic Material

8-Hydroxy-1-octanethiol

8-Hydroxy-1-octanethiol

Self Assembled Monolayer Reagent

  • Product code
    H338  8-Hydroxy-1-octanethiol
  • CAS No.
    33065-54-2
  • Chemical name
    8-Hydroxy-1-Octanethiol
  • MW
    C8H18OS=162.29
Unit size Price Item Code
10 mg $152.00 H338-10
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Product Description

Hydroxyalkanethiols are utilized as dilution reagents on a gold surface to control the density of reactive groups, or as blocking agents to prevent non-specific binding of analytes on the surface. Newly developed 16-Hydroxy-1-hexadecanethiol has a 16-carbon chain which is the longest alkanethiol available in the market among hydroxyalkanethiols. In all, there are a total of 6 different hydroxyalkanethiols including Hydroxy-EG6-undecanethiol and Hydroxy-EG3-undecanethiol available for gold surface modification. 16-Hydroxy-1-hexadecanethiol is used to prepare a homogeneous and highly oriented SAM when 16-Amino-1-hexadecanethiol or 15-Carboxy-1-pentadecanethiol is applied. Herne and his co-workers fabricated mixed SAMs of thiol-derivatized singlestranded DNA (HS-ss-DNA) and 6-Hydroxy-1-hexanethiol on a gold surface that prevented non-specific adsorption of HS-ss-DNA. Perez-Luna and others made mixed SAMs of biotin-terminated thiol and 11-hydroxy-1-undecanethiol on a gold surface. They prevented non-specific adsorption of wild type streptavidin and streptavidin mutants. Dubrovsky and coworkers controlled the non-specific adsorption of protein on the surface of gold-coated silicagel using 11-Hydroxy-1-undecanethiol. They mentioned the usefulness of gold-coated silica gel for the preparation of well-defined, surface-functionalized supports for biological assay.

References

Open References

1) T. M. Herne and M. J. Tarlov, "Characterizathion of DNA Probes Immobilized on Gold Surfaces", J. Am. Chem. Soc., 1997, 119, 8916.

Handling and storage condition

Specification
Appearance: Colorless to slightly yellow liquid
Purity (GC): ≧ 98.0 %
Handling and storage condition
-20°C, Nitrogen substitution
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Product Classification

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