Sulfo-AC5-SPDP

$758.00

Chemical Name: N-{6-[3-(2-Pyridyldithio)propionamido]hexanoyloxy}sulfosuccinimide,sodium salt
CAS: 169751-10-4

Appearance: White to almost white powder
Purity: ≥90.0% (HPLC)
MW: 527.57, C18H22N3NaO8S3

Storage Condition: -20ºC
Shipping Condition: with blue ice

Clear
DescriptionApplicationReferencesS.D.S
Product Description
Sulfo-AC5-SPDP is molecule containing N-hydroxysuccinimideactive ester groups. It may be introduced pyridyl disulfide group to the amino group of proteins such as antibodies and enzymes. Pyridyl disulfide group can be converted to SH group by a reducing agent. By exchange reaction with SH groups of proteins, it can be coupled with or protein carrier column via a disulfide bond. Since the active ester group having a sulfonic acid group is introduced, it is possible to carry out the labeling reaction without using an organic solvent such as DMSO or DMF.

other

Product Name Code Length (Å)
Sulfo-AC5-SPDP S359 12.6
1. A.K. Patri, A. Myc, J. Beals, T. P. Thomas, N. H. Bander and J. R. Baker, Jr.,”Synthesis and in vitro Testing of J591 Antibody-dendrimerConjugates for Targeted Prostate Cancer Therapy”, Bioconjugate Chem.,2004, 15(6), 1174.
2. N. W. S. Kam, Z. Liu and H. Dai, “Functionalization of Carbon Nanotubesvia Cleavable Disulfide Bonds for Efficient Intracellular Delivery of siRNA andPotent Gene Silencing”, J. Am. Chem.Soc.,2005, 127(36),12492.
3. A. M. Derfus, A. A. Chen, D-H. Min, E. Ruoslahti and S. N. Bhatia,”Targeted Quantum Dot Conjugates for siRNA Delivery”, BioconjugateChem., 2007, 18(5), 1391.
4. M. Ghasemi, M. Minier, M. Tatoulian and F. Arefi-Khonsari,”Determination of Amine and Aldehyde Surface Densities: Application to theStudy of Aged Plasma Treated Polyethylene Films”, Langmuir, 2007,23(23), 11554.
5. C. L. Waite and C. M. Roth, “PAMAM-RGD Conjugates Enhance siRNADelivery Through a Multicellular Spheroid Model of Malignant Glioma”, BioconjugateChem., 2009, 20(10), 1908.
6. R. Xu, M. Fisher and R. L. Juliano, “Targeted Albumin-BasedNanoparticles for Delivery of Amphipathic Drugs”,
Bioconjugate Chem., 2011, 22(5), 870.

Related Categories
Surface Chemistry

Related Products

COVID-19 Announcement

Due to rising concerns regarding the COVID-19 (Coronavirus 2019) outbreak, Dojindo Molecular Technologies, Inc will be taking the necessary steps to prioritize public health and safety.

Scroll to Top