Product Description of S-Nitrosothiols
Nitrosothiol compounds release NO and become disulfides under specific physiological conditions. While most of the S-nitrosothiol compounds are unstable, S-Nitrosoglutathione is exceptionally stable. Furthermore, S-Nitrosoglutathione is water-soluble. Although S-nitrosothiol is a good NO donor with no nitrate tolerance, there is evidence that S-nitrosothiol itself has NO-like activity during guanylate cyclase activation. Another important reaction of nitrosothiol is NO transfer to other thiol compounds. Since it depends on the pKa of thiols, this transfer reaction proceeds at physiological pH levels. The relaxation efficiency of these nitrosothiol has been compared using rataprta ring samples:SNAP > S – N i t r o s o g l u t a t h i o n e = S – N i t r o s o – N -acetylcysteine>S-Nitrosocoenzyme A>S-Nitroso-L-cysteine. Dr. Kowaluk and others reported that the spontaneous liberation of NO from SNAP could not account for in vitro vascular relaxation. The spontaneous release of NO from nitrosothiol compounds may not be a key element of vascular relaxation. Metabolites of nitrosothiol generated at the cell membrane might be the essential element for relaxation.
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