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Carboxylic acid-SAM Formation reagent
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For Research Use Only Products
Easily forms carboxy-terminated monolayers on gold
Suppress non-specific binding
Appearance: Colorless or pale yellow liquid
Keyword: SAM, Self-Assembled Monolayers
SPR (Surface Plasmon Resonance)
QCM (Quartz Crystal Microbalance)
biosensors, protein immobilization
Product Description
Carboxylic acid-SAM Formation Reagent is used to prepare carboxylic acid- terminated self-assembled monolayers (SAMs) on gold surfaces as biosensors detected by QCM (Quartz Crystal Microbalance), SPR (Surface Plasmon Resonance), and electrochemical analysis. Coupled with carboxyl group activation method using NHS/WSC, carboxylic acid-SAM can be used as an interface to immobilize proteins or peptides and other ligands on gold surfaces (Fig. 1). In general, carboxylic acid-SAM provides some non-specific binding because of its negative charge. However, surfaces prepared using -carboxylic acid-SAM Formation Reagent presents less non-specific binding than thiose commonly prepared with carboxylic acid-SAM (Fig. 2). Fig. 1 A biosensor construction by Carboxylic acid-SAM Formation Reagent
Fig. 2 Comparison of non-specific binding between carboxylic acid-SAM prepared with carboxylic acid-SAM Formation Reagent and commonly prepared SAM