Ins(1,4,5)P3 (synthetic)

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Ins(1,4,5)P3 (synthetic) (100µg) - I007-10

Ins(1,4,5)P3 (synthetic) (1mg) - I007-12

Item #	Description/Size	Availability	Qty Break	Price	Quantity
I007-10	100 µg	5-10 business days	1	$151.00
I007-12	1 mg	5-10 business days	1	$367.00

*Estimated. Exact shipping date will be notified.
For Research Use Only Products

Description
Application

Chemical Name: D-myo-Inositol-1,4,5-triphosphate, tripotassium salt
CAS: 85166-31-0

Appearance: White pellet
Purity: pass test (TLC)
MW: 534.37, C₆H₁₂K₃O₁₅P₃

Storage Condition: -20^ºC, protect from light
Shipping Condition: ambient temperature

Product Description

Inositol phosphates and diacylglycerols are generated from phosphatidyl inositols by phospholipase C. They are involved in cellular calcium ion movements as second messengers. Inositol-1,4,5-triphosphate(Ins(1,4,5)P3) is an extremely important messenger that triggers calcium ion release from endoplasmic and sarcoplasmic reticulum. It is thought to increase the calcium sensitivity of the inositol- induced calcium release(IICR) channel in the intracellular calcium source. Thus, the IICR channel can be opened with a low level of calcium ion concentration, causing a dramatic calcium burst into the cytosol. The released calcium ions and diacylglycerol then activate protein kinase C, which is one of the key enzymes in signal transduction.

Chemical Structure

References
1. M. Hirata, et al., Synthetic Inositol Trisphosphate Analogs and Their Effects on Phosphatase, Kinase, and the Release of Ca2+. J Biol Chem. 1989;264:20303-20308.