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Home > Protein Analysis > Cross-Linking Reagents >
*Estimated. Exact shipping date will be notified.
For Research Use Only Products
Chemical Name: N-Succinimidyl 3-(2-pyridyldithio)propionate
CAS: 68181-17-9
Appearance: Amine and sulfhydryl group cross-linking
Purity: ≥98.0% (HPLC)
MW: 312.37, C12H12N2O4S2
Storage Condition: 0-5ºC,
Shipping Condition: ambient temperature
Product Description
SPDP, a hetero-bifunctional reagent, is useful for bridging two different proteins, such as enzymes and antibodies. SPDP first reacts with a protein molecule through its amino groups. SPDP introduces a pyridyl disulfide moiety to the protein, which is then reduced by DTT to form thiol groups. These thiol groups then form a disulfide bond with another protein molecule thus yielding a heterodimer protein.
Structural Formula:
References
1. P. Walden, Z. A. Nagy and J. Klein, Major Histocompatibility Complex-Restricted and Unrestricted Activation of Helper T Cell Lines by Liposome-bound Antigens, J. Mol. Cell. Immunol, 1986, 2, 191.
2. R. D. Gordon, W. E. Fieles, D. L. Schotland, R. Hogue-Angeletti and R. L. Barchi, Topographical Localization of the C-terminal Region of the Voltagedependent Sodium Channel from Electrophorus Electricus Using Antibodies Raised Against a Synthetic Peptide, Proc. Natl. Acad. Sci. USA, 1987,
84, 308.
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GMBS
Cross-Linking Reagents
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HMCS
Cross-Linking Reagents
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KMUS
Cross-Linking Reagents
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EMCS
Cross-Linking Reagents
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All Products are applicable only for life science research. Not for diagnostic research use.
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