Isothiocyanobenzyl-EDTA

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Isothiocyanobenzyl-EDTA (10mg) - M030-10

Item #	Description/Size	Availability	Qty Break	Price	Quantity
M030-10	10 mg	5-10 business days	1	$420.00

*Estimated. Exact shipping date will be notified.
For Research Use Only Products

Description
Application

Chemical Name: 1-(4-Isothiocyanatobenzyl)ethylenediamine-N,N,N EN Etetraacetic acid
CAS: 105394-74-9

Appearance: Slightly yellowish-brown powder
Purity: ≥90.0% (HPLC)
MW: 439.44, C₁₈H₂₁N₃O₈S

Storage Condition: -20^oC
Shipping Condition: ambient temperature

Product Description of Amine-Reactive Biotins

Isothiocyanobenzyl-EDTA adds EDTA moieties to proteins through their amine groups. The EDTA-tagged protein can then be labeled with heavy metal ions and radioactive metals, such as ¹¹¹In and ⁹⁹Tc, and used for immunoimaging.

Chemical Structure

References

1. C. F. Meares and T. G. Wensel, Metal Chelates as Probes of Biological Systems, Acc. Chem. Res.,1984, 17, 202.
2. S. V. Deshpande, R. Subramanian, M. J. McCall, S. J. Denardo, G. L. Denardo and C. F. Meares, Metabolism of Indium Chelates Attached to Monoclonal Antibody: Minimal Transchelation of Indium form Benzyl-EDTA Chelate in vivo, J. Nucl. Med., 1990, 31, 218.
3. S. Mirzadeh, M. W. Brechbiel and R. W. Atcher, Otto A. Gansow Radiometal Labeling of Immunoproteins: Covalent Linkage of 2-(4-Isothiocyanatobenzyl) diethylenetriaminepentaacetic acid Ligands to Immunoglobulin, Bioconjugate Chem., 1990, 1, 59.